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The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop.
THE BINDING SITE OF AMINERGIC G PROTEINCOUPLED RECEPTORS The Transmembrane Segments and Second Extracellular Loop
Annual Review of Pharmacology and Toxicology 42 (1), 437 (2002)
info:doi/10.1146/annurev.pharmtox.42.091101.144224
Posted by xdeupi to ecl2 transmembrane loops helix agonist binding GPCR on Thu Sep 07 2006 at 13:00 UTC | info | related
 
Possible role of the 11-cis-retinyl conformation in controlling the dual decay processes of excited rhodopsin.
Supramolecular Structure and Dynamics Special Feature Possible role of the 11cisretinyl conformation in controlling the dual decay processes of excited rhodopsin
Robert S H Liu, George S Hammond, and Taraneh Mirzadegan
Proceedings of the National Academy of Sciences of the United States of America. 102 (31), 10783-7 (02 Aug 2005)
info:pmid/16043701 | info:doi/10.1073/pnas.0501665102
Posted by xdeupi and 1 other to activation binding GPCR Rhodopsin on Thu Sep 07 2006 at 13:00 UTC | info | related
 
Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin.
Tara Mirzadegan et al.
Biochemistry. 42 (10), 2759-67 (18 Mar 2003)
info:pmid/12627940 | info:doi/10.1021/bi027224+
Posted by xdeupi to activation GPCR Rhodopsin sequence on Thu Sep 07 2006 at 13:00 UTC | info | related
 
Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions.
Evolutionary Trace of G Proteincoupled Receptors Reveals Clusters of Residues That Determine Global and Classspecific Functions
Journal of Biological Chemistry 279 (9), 8126 (2003)
info:doi/10.1074/jbc.m312671200
Posted by xdeupi to switch activation binding GPCR sequence on Thu Sep 07 2006 at 13:00 UTC | info | related
 
Lessons from constitutively active mutants of G protein-coupled receptors.
Charles Parnot et al.
Trends in endocrinology and metabolism: TEM. 13 (8), 336-43 (Oct 2002)
info:pmid/12217490
Posted by xdeupi to CAM activation GPCR on Thu Sep 07 2006 at 13:00 UTC | info | related
 
The ants go marching two by two: oligomeric structure of G-protein-coupled receptors.
Jonathan A Javitch
Molecular pharmacology. 66 (5), 1077-82 (Nov 2004)
info:pmid/15319448 | info:doi/10.1124/mol.104.006320
Posted by xdeupi to dimer GPCR on Thu Sep 07 2006 at 13:00 UTC | info | related
 
Agonist binding: a multistep process.
Agonist Binding A Multistep Process
Brian Kobilka
Molecular Pharmacology 65 (5), 1060-2 (01 May 2004)
info:doi/10.1124/mol.65.5.1060
Posted by xdeupi to b2ar agonist activation binding GPCR on Thu Sep 07 2006 at 13:00 UTC | info | related
 
New concepts in drug discovery: collateral efficacy and permissive antagonism.
NEW CONCEPTS IN DRUG DISCOVERY COLLATERAL EFFICACY AND PERMISSIVE ANTAGONISM
Terry Kenakin
Nature Reviews Drug Discovery 4 (11), 919-27 (Nov 2005)
info:doi/10.1038/nrd1875
Posted by xdeupi and 2 others to Ligands agonist activation CCR5 GPCR on Thu Sep 07 2006 at 13:00 UTC | info | related
 
The physiological significance of constitutive receptor activity.
Trends in Pharmacological Sciences 26 (12), 603 (2005)
info:doi/10.1016/j.tips.2005.10.007
Posted by xdeupi to CAM activation GPCR on Thu Sep 07 2006 at 13:00 UTC | info | related
 
Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors.
Trends in Pharmacological Sciences 26 (12), 618 (2005)
info:doi/10.1016/j.tips.2005.10.009
Posted by xdeupi to CAM activation GPCR on Thu Sep 07 2006 at 13:00 UTC | info | related

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