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N-benzyladriamycin-14-valerate (AD 198) activates protein kinase C-delta holoenzyme to trigger mitochondrial depolarization and cytochrome c release independently of permeability transition pore opening and Ca2+ influx.
Leonard Lothstein et al.
Anti-cancer drugs. 17 (5), 495-502 (Jun 2006)
info:pmid/16702805
PTP and Ca+ not essential for apoptosis
Posted by rberney to Bcl Apoptosis Deltapsim mtp depolarization citochrome c on Tue May 30 2006 at 22:05 UTC | info | related
 
Sphingosine impairs mitochondrial function by opening permeability transition pore.
Sidi Mohamed Hassoun et al.
Mitochondrion, (11 May 2006)
info:pmid/16725383 | info:doi/10.1016/j.mito.2006.05.001
Sphingosine induces reductions in ADP-coupled respiration, membrane potential, cytochrome c and ATP production
Posted by rberney to cytochrome c mtp ATP BCL-2 cotosporin A on Tue May 30 2006 at 21:52 UTC | info | related
 
The neuroprotection conferred by activating the mitochondrial ATP-sensitive K(+) channel is mediated by inhibiting the mitochondrial permeability transition pore.
Liping Wu et al.
Neurosci Lett 402 (1-2), 184-9 (10 Jul 2006)
info:pmid/16678347 | info:doi/10.1016/j.neulet.2006.04.001
mitochondria transition pore
Posted by rberney to mtp Katp brain cytosporin a diazoxide on Tue May 30 2006 at 20:01 UTC | info | related

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