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N-benzyladriamycin-14-valerate (AD 198) activates protein kinase C-delta holoenzyme to trigger mitochondrial depolarization and cytochrome c release independently of permeability transition pore opening and Ca2+ influx.
Leonard Lothstein et al.
Anti-cancer drugs. 17 (5), 495-502 (Jun 2006)
info:pmid/16702805
PTP and Ca+ not essential for apoptosis
Posted by rberney to Bcl Apoptosis Deltapsim mtp depolarization citochrome c on Tue May 30 2006 at 22:05 UTC | info | related

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