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Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.
Yoshinori Nagai et al.
Immunity. 24 (6), 801-12 (Jun 2006)
TL2 and TL4 ligation shift myelopoyesis towards CD62Lhigh/Gr1+ monocytes and lymphopoyesis towards CD11b/CD11c dendritic cells.
 
IMMUNOLOGY: Targeting the Tolls
Ingrid Wickelgren
Science 312 (5771), 184-7 (14 Apr 2006)
History and future of the research on TLRs
Posted by pedrohorna to TLR history review on Tue May 02 2006 at 02:36 UTC | info | related
 
A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation
Nobutaka Suzuki et al.
Science 311 (5769), 1927-32 (31 Mar 2006)
IRAK4 is involved in T-cell signaling.
 
Toll-dependent selection of microbial antigens for presentation by dendritic cells.
J Magarian Blander and Ruslan Medzhitov
Nature., published online 19 Feb 2006
Colocalization on TLR ligand with antigen is important for presentation on MHC by DCs.
 
All is not Toll: new pathways in DNA recognition
Hermann Wagner and Stefan Bauer
The Journal of Experimental Medicine 203 (2), 265-8 (21 Feb 2006)
Posted by pedrohorna to TLR review on Wed Feb 22 2006 at 17:23 UTC | info | related
 
Innate immune recognition of viral infection
Taro Kawai and Shizuo Akira
Nature immunology 7 (2), 131-7 (Feb 2006)
Notes about TLR signaling, specially TLR3,7,8 and 9 (viral responses) and well as intracellular receptors.
Posted by pedrohorna and 1 other to TLR review on Mon Jan 30 2006 at 23:22 UTC | info | related
 
Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity
Nicholas S Wilson et al.
Nat Immunol 7 (2), 165-72 (15 Jan 2006)
Antigen uptake by DCs freezes in-vivo in response to TLRs.
 
Ruslan Medzhitov. Ph.D.
www.hhmi.org
Analysis of the innate immune system, innate control of adaptive immunity, and host-pathogen and host-commensal interactions.
Posted by pedrohorna to Researchers TLR on Fri Jan 27 2006 at 22:02 UTC | info | related
 
IκBNS Inhibits Induction of a Subset of Toll-like Receptor-Dependent Genes and Limits Inflammation
Immunity 24 (1), 41 (2006)
IkBNS KO mice have increase suceptibility to LPS and their macrophages produce more IL-12.
 
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
Gregory Barton, Jonathan Kagan, and Ruslan Medzhitov
Nature immunology. 7 (1), 49-56 (Jan 2006)
Posted by pedrohorna and 3 others with 1 comment to TLR on Thu Jan 12 2006 at 23:55 UTC | info | related

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