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OX40 Costimulation Synergizes with GM-CSF Whole-Cell Vaccination to Overcome Established CD8+ T Cell Tolerance to an Endogenous Tumor Antigen
Satoshi Murata et al.
The Journal of Immunology 176 (2), 974-83 (15 Jan 2006)
MMTV-neu trasngenic mice cannot develop a neu-specific CTL response or the rejection of neu-expressing tumors upon vaccination against neu. OX40 costimulation can allow for an effective immunization in these animals.
Posted by pedrohorna and 1 other with 1 comment to cancer vaccines costimulation tumor immunology T-cell tolerance CD8 T-cells autoimmunity self tumor antigens MMTV tolerance reversal on Mon Mar 13 2006 at 16:18 UTC | info | related
 
HER-2/neu Is a Tumor Rejection Target in Tolerized HER-2/neu Transgenic Mice
R. Todd Reilly et al.
Cancer Research 60 (13), 3569-76 (01 Jul 2000)
Depite peripheral tolerance to Neu, a modest anti-tumor immunity can be elicited against neu expressing tumors by GMCSF cell vaccine or viral recombinant vaccines.
Posted by pedrohorna with 1 comment to cancer vaccines tumor immunology T-cell tolerance self tumor antigens MMTV tolerance reversal on Sun Mar 12 2006 at 17:17 UTC | info | related

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