The ability of a U.S. Army vehicle or a piece of equipment to decontaminate itself in situ from the threat of chemical agents is highly desirable and may reduce the weight and logistical footprints associated with decontamination operations. This work explores the ability of several nanometal oxide powders (that could potentially be incorporated into U.S. Army coatings) to decontaminate 2-chloroethyl ethyl sulfide, a simulant for the blister agent sulfur mustard. Another mustard stimulant, 2-chloroethyl phenyl sulfide, and a simulant for the nerve agent GB, dimethyl methylphosphonate, were also examined.