..."Remarkebly, approximately 80% of MRSA were susceptible to doxycycline."..."CONCLUSION: Resistance to various antibiotics except doxycycline is associated with MRSA, but not MSSA. MRSA appear to be nosocomial pathogens favoured by selection, which can be controlled by hygienic measures. "

..."Treatment: Mild-moderate disease usually presents as soft tissue abscesses or cellulites. Many respond with drainage alone. When antibiotics are given, the recommendation is clindamycin (if the D test is negative), trimethoprim-sulfamethoxazole, or doxycycline. For severe disease the recommendation for empiric treatment is vancomycin plus nafcillin +/- gentamicin. Linezolid is another option. "..

"To evaluate empirical therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus, a randomized, prospective, open-label investigation was performed. The overall clinical failure rate was 9%, with all failures occurring in the trimethoprim-sulfamethoxazole group. However, there was no significant difference between the clinical failure rate of empirical trimethoprim-sulfamethoxazole therapy and that of doxycycline therapy. ".."All 3 clinical failures occurred in the trimethoprim-sulfamethoxazole group (3 failures out of 14 [21%] subjects on trimethoprim-sulfamethoxazole therapy), with no clinical failures in the doxycycline group."...

..."Antimicrobial harms have gained the attention of practicing clinicians and hospital formulary committees, because they top the list of drugs that are associated with adverse events and because of certain serious harms that have ultimately led to the withdrawal of some antimicrobial agents. In the near future, several antimicrobials in the late phase of development will become available for clinical use (ceftobiprole, ceftaroline, and telavancin), and others (doripenem and dalbavancin) have recently joined the armamentarium. Because new antimicrobials will become part of the treatment armamentarium, it is important to discuss our current understanding of antimicrobial harms in general. Although not thought of as traditional adverse events, Clostridium difficile infection and development of resistance during therapy are adverse events that occur as a result of antimicrobial exposure and therefore are discussed. In addition, a distillation of our current understanding of β-lactam specific adverse events will be provided. Finally, new methods of administration are being evaluated that may influence peak concentration-related antimicrobial adverse events."..."In addition, the US Food and Drug Administration (FDA) recently mandated a second change in the labeling of telithromycin in less than a year because of safety concerns, and has updated the language of antimicrobials regarding the risk for Clostridium difficile infection [1]. Antibiotic safety is an important component of both patient care and formulary decision making."..."Type A events are predictable events that represent either an excess of the drug's primary pharmacologic effect (for example, hypotension with a vasodilator) or a secondary pharmacologic property (for example, anticholinergic effects with tricyclic antidepressants) [2]. ".."In contrast, type B events are not an extension of the known pharmacologic properties of a drug. These events, which include idiosyncratic, immunologic/allergic, and carcinogenic/teratogenic events, are generally unpredictable, unrelated to dosing or route of administration, and are more or less a function of the patient's susceptibility to the effect rather than intrinsic drug toxicity. Type B events can present late, long after drug therapy has been discontinued, and consequently they may not be recognized or attribut