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Investigations of a human embryonic globin gene silencing element using YAC transgenic mice.
Patrick Navas et al.
Experimental biology and medicine (Maywood, N.J.) 231 (3), 328-34 (Mar 2006)
silencer doesn't have any effect on gene expression if knocked out in genomic context
 
The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1.
Berthold Göttgens et al.
Molecular and cellular biology 24 (5), 1870-83 (Mar 2004)
enhancers is not necessary if genomic context is present

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