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Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling.
Yufeng Yang et al.
Proceedings of the National Academy of Sciences of the United States of America. 102 (38), 13670-5 (20 Sep 2005)
DJ-1A, a Drosophila homologue of the familial PD-associated gene DJ-1, plays an essential role in oxidative stress response and neuronal maintenance. They found reduced phosphorylation of Akt in DJ-1A RNAi animals, indicating an impairment of PI3K/Akt signaling by DJ-1A down-regulation.
 
Requirement of Akt to mediate long-term synaptic depression in Drosophila.
Hui-Fu Guo and Yi Zhong
The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 (15), 4004-14 (12 Apr 2006)
First report of LTD in Drosophila NMJ. Learning mutants, such as rutabaga, dunce, and latheo, did not affect LTD.

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