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Genetic Variation in PTPN22 Corresponds to Altered Function of T and B Lymphocytes
Mary Rieck et al.
The Journal of Immunology 179 (7), 4704-10 (01 Oct 2007)
Gain of function
Posted by jbowes to PTPN22 on Wed May 07 2008 at 12:57 UTC | info | related
 
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.
Torkel Vang et al.
Nature genetics 37 (12), 1317-9 (Dec 2005)
info:pmid/16273109 | info:doi/10.1038/ng1673
Gain of function
Posted by jbowes to PTPN22 on Wed May 07 2008 at 12:56 UTC | info | related
 
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.
Nunzio Bottini et al.
Nature genetics 36 (4), 337-8 (Apr 2004)
info:pmid/15004560 | info:doi/10.1038/ng1323
Posted by jbowes to PTPN22 on Wed May 07 2008 at 12:54 UTC | info | related
 
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
Ann B Begovich et al.
American journal of human genetics 75 (2), 330-7 (Aug 2004)
info:pmid/15208781 | info:doi/10.1086/422827
Posted by jbowes to PTPN22 on Wed May 07 2008 at 12:54 UTC | info | related
 
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.
Chieko Kyogoku et al.
American journal of human genetics 75 (3), 504-7 (Sep 2004)
info:pmid/15273934 | info:doi/10.1086/423790
Posted by jbowes to PTPN22 on Wed May 07 2008 at 12:54 UTC | info | related
 
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.
Deborah Smyth et al.
Diabetes 53 (11), 3020-3 (Nov 2004)
info:pmid/15504986
Posted by jbowes to PTPN22 on Wed May 07 2008 at 12:54 UTC | info | related
 
The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease.
M R Velaga et al.
The Journal of clinical endocrinology and metabolism 89 (11), 5862-5 (Nov 2004)
info:pmid/15531553 | info:doi/10.1210/jc.2004-1108
Posted by jbowes to PTPN22 on Wed May 07 2008 at 12:53 UTC | info | related
 
The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis.
Ann B Begovich et al.
American journal of human genetics 76 (1), 184-7 (Jan 2005)
info:pmid/15580548 | info:doi/10.1086/427244
Posted by jbowes to PTPN22 on Wed May 07 2008 at 12:53 UTC | info | related
 
Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus.
Gisela Orozco et al.
Arthritis and rheumatism 52 (1), 219-24 (Jan 2005)
info:pmid/15641066 | info:doi/10.1002/art.20771
Posted by jbowes to PTPN22 on Wed May 07 2008 at 12:53 UTC | info | related
 
Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene.
Anne Hinks et al.
Arthritis and rheumatism 52 (6), 1694-9 (Jun 2005)
info:pmid/15934099 | info:doi/10.1002/art.21049
Posted by jbowes to PTPN22 on Wed May 07 2008 at 12:53 UTC | info | related

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