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jason's bookmarks matching tag sca

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Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation.

Aaron B Bowman et al.

Hum Mol Genet 14 (5), 679-91 (01 Mar 2005)

info:pmid/15661755 | info:doi/10.1093/hmg/ddi064

Posted by jason and 1 other to polyglutamine ups sca polyQ on Tue Aug 16 2005 at 18:14 UTC | info | related

Misfolding promotes the ubiquitination of polyglutamine-expanded ataxin-3, the defective gene product in SCA3/MJD.

Nihar Ranjan Jana and Nobuyuki Nukina

Neurotox Res 6 (7-8), 523-33 (2004)

info:pmid/15639784

Posted by jason and 1 other to ataxin polyQ sca neurodegeneration protein folding on Mon Jun 06 2005 at 21:11 UTC | info | related

Protein surveillance machinery in brains with spinocerebellar ataxia type 3: redistribution and differential recruitment of 26S proteasome subunits and chaperones to neuronal intranuclear inclusions.

Thorsten Schmidt et al.

Ann Neurol 51 (3), 302-10 (Mar 2002)

info:pmid/11891825

Posted by jason and 1 other to proteasome sca polyQ Chaperones on Fri Jun 03 2005 at 15:47 UTC | info | related

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