creased levels of f-5HT in plasma, during asthma attacks, were associated with clinical severity and pulmonary function.4 In 1998, we published two research articles showing that tianeptine (a serotonin uptake enhancing drug, which reduces plasma f-5HT) provoked a dramatic and sudden decrease of both clinical rating and f-5HT plasma levels as well as an increase in pulmonary function.5 6