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Modelling molecular stability in the RNA world
Computational Biology and Chemistry 29 (4), 259 (2005)
RNA secondary structure, stability and melting curves are calculated for a model of a possible ribozyme corresponding to the RNA directed RNA polymerase (ribopolymerase) required in the RNA world. From these calculations, rates of folding and hybridisation are estimated and used in a stochastic simulation of the dynamics of a population of ribopolymerase molecules. Two models are considered: one synthesising a conventional antiparallel reverse complementary transcript and one synthesising a parallel complementary transcript. It was found that the latter system can operate much more effective in the higher temperatures thought to prevail during the RNA world.
Posted by bpb to rna-world RNA origin-of-life on Wed Apr 30 2008 at 11:29 UTC | info | related

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