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Ficolin-2 recognizes DNA and participates in the clearance of dying host cells.
Maria Lund Jensen et al.
Mol Immunol, (24 May 2006)
Authors attempt to demonstrate that FCN2 binds to late apoptotic and necrotic cells by binding to DNA. Compliment activation data was unconvincing. DNA dot blot looked good - positive for FCN binding, but GlcNAc was unable to compete for binding, suggesting FCNs bind to DNA via the tails, not the fibrinogen like lectin domain. Binding was Ca++ dependent.
Posted by bguikema with 1 comment to ficolin Apoptosis on Wed Jun 14 2006 at 16:58 UTC | info | related

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