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Generation of Abeta 38 and Abeta 42 is independently and differentially affected by FAD-associated presenilin 1 mutations and gamma -secretase modulation.

Richard M Page et al.

J Biol Chem, (24 Oct 2007)

info:pmid/17962197 | info:doi/10.1074/jbc.M708754200

Posted by akraeutl1 to amyloid b-peptide proteolytic processing b-amyloid precursor protein APP non-steroidal anti-inflammatory drugs nsaid sulindac sulfide Ab42 Ab38 different familial AD FAD presenilin ps CATALYTIC SUBUNIT g-secretase PS1 FAD-associated M146L A285V Mutations fenofibrate derivative ps2 In Vitro in vivo transgenic mice expressing N141I Modulation secretase Haass steiner Perez-Revuelta Tomioka page on Sat Jan 05 2008 at 21:14 UTC | info | related

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