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Haploinsufficiency of the mSds3 chromatin regulator promotes chromosomal instability and cancer only upon complete neutralization of p53
G David et al.
Oncogene 25 (56), 7354-60 (12 Jun 2006)
mSds3, an essential component of the Sin3 histone deacetylase complex, has a further role in chromosome segregation. mSds3 +/- p53 -/- mice have increased aneuploidy and tumorigenesis compared to mSin3A +/- p53 -/- mice (where mSin3A is another component of the Sin3 complex).

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