On the results of high throughput MS analysis of phosphorylated S.cerevisiae, S.pombe, and C.albicans are presented here. Though all three species are phosphoarylated on simliar proteins/residues, differences between the organisms can be gleaned. Particularly, the ORC and MCM complexes appear to be phosphorylated, as a complex, but not necessarily at the same components or residues in all species. Also, they compared the changes to TF/target interactions and show that phospho-changes happen more slowly than TF-target changes. Additionally, they overlaid the results onto som E-MAP data that seems to indicate that protein kinases are less conserved via genetic interactions than other proteins.