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Journal of pharmacokinetics and pharmacodynamics 33 (3), 227-79 (Jun 2006)
DA - 20060707
LA - eng
PT - Historical Article
PT - Journal Article
PT - Research Support, N.I.H., Extramural
PT - Review
SB - IM
Journal of Veterinary Emergency and Critical Care 18 (2), 153-7
American Journal of Veterinary Research 61, 651 (2000)
The Journal of Clinical Pharmacology 47 (2), 146-58 (01 Feb 2007)
The Journal of Clinical Pharmacology 47 (10), 1256-67 (01 Oct 2007)
Real pharmacokinetic differences:
"The selegiline pharmacokinetics differed greatly between the 2 routes of administration. Transdermal selegiline administration reduced metabolism and produced a high, sustained plasma selegiline concentration over the dosing period, with an absolute bioavailability of 73%. By contrast, oral dosing produced a sharp plasma selegiline peak that occurred within 1 hour and declined rapidly, with an absolute bioavailability of 4%. The data provide the basis for therapeutic advantages of the selegiline transdermal system in administering antidepressant doses of selegiline."
Marked effect of liver and kidney function on the pharmacokinetics of selegiline
Clinical Pharmacology & Therapeutics 77 (1), 54 (2005)
Cancer Epidemiology Biomarkers Prevention 17 (6), 1411-7 (01 Jun 2008)
International journal of radiation oncology, biology, physics 36 (2), 417-28 (01 Sep 1996)
0360-3016
Population Pharmacokinetic and Pharmacodynamic Analysis of a Class IC Antiarrhythmic Pilsicainide in Patients With Cardiac Arrhythmias
The Journal of Clinical Pharmacology 46 (1), 59-68 (01 Jan 2006)
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