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Neuroligins and neurexins link synaptic function to cognitive disease
Thomas Sudhof
Nature 455 (7215), 903-11 (16 Oct 2008)
Posted by Cyril and 3 others to neuroligin neurexin review on Tue Feb 03 2009 at 21:59 UTC | info | related
 
Alternative splicing controls selective trans-synaptic interactions of the neuroligin-neurexin complex.
Ben Chih, Leora Gollan, and Peter Scheiffele
Neuron. 51 (2), 171-8 (20 Jul 2006)
Posted by Cyril and 1 other to neuroligin neurexin on Mon Jan 19 2009 at 21:26 UTC | info | related
 
Neuroligins and neurexins: linking cell adhesion, synapse formation and cognitive function.
Camin Dean and Thomas Dresbach
Trends in neurosciences. 29 (1), 21-9 (Jan 2006)
Posted by Cyril and 2 others to neuroligin neurexin cognitive on Mon Jan 19 2009 at 21:24 UTC | info | related
 
Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins.
Ethan R Graf et al.
Cell 119 (7), 1013-26 (29 Dec 2004)
 
The neuroligin and neurexin families: from structure to function at the synapse.
M-F Lisé and A El-Husseini
Cellular and molecular life sciences : CMLS 63 (16), 1833-49 (23 Jun 2006)
Posted by Cyril and 1 other to neuroligin neurexin on Mon Jan 19 2009 at 21:18 UTC | info | related
 
Activity-independent and subunit-specific recruitment of functional AMPA receptors at neurexin/neuroligin contacts
Martin Heine et al.
Proceedings of the National Academy of Sciences of the United States of America 105 (52), (19 Dec 2008)
 
Neuroligins Determine Synapse Maturation and Function
Neuroligins determine synapse maturation and function
Neuron 51 (6), 741 (2006)
"his is a landmark paper showing that neuroligins are essential for synapse function in vivo. Although individual neuroligin knockout mice are viable, Nlgn1;Nlgn2;Nlgn3 triple knockout mice die at birth owing to respiratory failure. Their synapses seem to be morphologically normal, but transmission was dramatically reduced at GABAergic/glycinergic synapses, and also reduced at glutamatergic synapses, in the brainstem. This was accompanied by reduced clustering of GABAA receptors, reduced levels of synaptic vesicle proteins and a slight reduction in the ratio of VGAT puncta to VGlut puncta, but clustering of the scaffolding proteins PSD-95 and gephyrin was normal."
 
Neurexin–neuroligin signaling in synapse development
Current Opinion in Neurobiology 17 (1), 43 (2007)
 
High frequency of neurexin 1beta signal peptide structural variants in patients with autism.
Jinong Feng et al.
Neurosci Lett, (09 Oct 2006)
4/203 (only in about 2% of cases) vs. 0/535, P=0.0056
 
Neuroligins and neurexins: linking cell adhesion, synapse formation and cognitive function.
Camin Dean and Thomas Dresbach
Trends in neurosciences. 29 (1), 21-9 (Jan 2006)

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