Free online reference management for clinicians and scientists

Sign up now

Recent "listeria" articles

  • These articles and links have been posted by Connotea users using the tag "listeria".
  • To add to this collection, or to start your own library:

Learn more

Watch a short video (2m 41s)

EXPORT LIST RSS ?
Bookmarks matching tag listeria
 
Number of articles per page:
10 | 25 | 50 | 100
 
Listeria monocytogenes, a unique model in infection biology: an overview
www.sciencedirect.com
This review rather than covering the whole field intends to highlight recent findings on the Listeria monocytogenes infectious process or some Listeria specific traits, place them within the framework of well-established data, and demonstrate how this Gram-positive bacterium has, in two decades, emerged as a multifaceted paradigm. Indeed, the cell biology of the infectious process has been deciphered in great detail and provided insights in both the way bacterial pathogen manipulate the host and unsuspected functions of well-known cellular proteins. The intra- and intercellular motility has in particular been instrumental in understanding actin-based motility in general. The analysis of the two main Listeria invasion proteins and that of their host specificities have illustrated how in vitro studies can help generating or choosing relevant animal models for in vivo studies. Listeria post-genomics studies have highlighted the power of comparative genomics in virulence studies. Together, Listeria, after being recognized as a powerful tool in immunology, now appears as one of the most insightful models in infection biology.
 
Liver invariant NKT cells and listeriosis
www.sciencedirect.com
The invariant (i) NKT cells represent unique T lymphocytes expressing TCRVα14. Although iNKT cells have been regarded as T lymphocytes expressing NK1.1, they do not consistently express this marker. NK1.1 allows recognition of “missing-self” and thus controls inhibition/activation of iNKT cells. It is thus tempting to assume that iNKT cells participate in the regulation of host immune responses during microbial infection by controlling NK1.1 expression. These findings shed light on the unique role of iNKT cells in microbial infection and provide an evidence for unique aspects of the NK1.1 on these cells as a regulatory molecule.
 
High Sensitivity of Intestinal CD8+ T Cells to Nucleotides Indicates P2X7 as a Regulator for Intestinal T Cell Responses.
Kirsten Heiss et al.
Journal of immunology (Baltimore, Md. : 1950) 181 (6), 3861-9 (15 Sep 2008)
The purinoreceptor P2X7 is expressed on subsets of T cells and mediates responses of these cells to extracellular nucleotides such as ATP or NAD(+). We identified P2X7 as a molecule highly up-regulated on conventional CD8alphabeta(+) and unconventional CD8alphaalpha(+) T cells of the intestinal epithelium of mice. In contrast, CD8(+) T cells derived from spleen, mesenteric lymph nodes, and liver expressed only marginal levels of P2X7. However, P2X7 was highly up-regulated on CD8(+) T cells from spleen and lymph nodes when T cells were activated in the presence of retinoic acid. High P2X7 expression on intestinal CD8(+) T cells as well as on CD8(+) T cells incubated with retinoic acid resulted in enhanced sensitivity of cells to extracellular nucleotides. Both cell populations showed a high level of apoptosis following incubation with NAD(+) and the ATP derivative 2',3'-O-(benzoyl-4-benzoyl)-ATP, and injection of NAD(+) caused selective in vivo depletion of intestinal CD8(+) T cells. Following oral infection with Listeria monocytogenes, P2X7-deficient mice showed similar CD8(+) T cell responses in the spleen, but enhanced responses in the intestinal mucosa, when compared with similarly treated wild-type control mice. Overall, our observations define P2X7 as a new regulatory element in the control of CD8(+) T cell responses in the intestinal mucosa.
 
PLoS Pathogens: XIAP Regulates Cytosol-Specific Innate Immunity to Listeria Infection
www.plospathogens.org
The inhibitor of apoptosis protein (IAP) family has been implicated in immune regulation, but the mechanisms by which IAP proteins contribute to immunity are incompletely understood. We show here that X-linked IAP (XIAP) is required for innate immune control of Listeria monocytogenes infection. Mice deficient in XIAP had a higher bacterial burden 48 h after infection than wild-type littermates, and exhibited substantially decreased survival. XIAP enhanced NF-κB activation upon L. monocytogenes infection of activated macrophages, and prolonged phosphorylation of Jun N-terminal kinase (JNK) specifically in response to cytosolic bacteria. Additionally, XIAP promoted maximal production of pro-inflammatory cytokines upon bacterial infection in vitro or in vivo, or in response to combined treatment with NOD2 and TLR2 ligands. Together, our data suggest that XIAP regulates innate immune responses to L. monocytogenes infection by potentiating synergy between Toll-like receptors (TLRs) and Nod-like receptors (NLRs) through activation of JNK- and NF-κB–dependent signaling.
 
Il-12 inversely regulates t-bet and eomesodermin expression during pathogen-Induced cd8+ Tcell differentiation
Cutting Edge IL12 Inversely Regulates Tbet and Eomesodermin Expression during PathogenInduced CD8 T Cell Differentiation
Naofumi Takemoto et al.
The Journal of Immunology 177 (11), 7515-9 (01 Dec 2006)
naofumi takemoto, et al. J Immunol. 2006 Dec 1;177(11):7515-9
 
Structural basis for the recruitment of profilin–actin complexes during filament elongation by Ena/VASP
The EMBO Journal 26 (21), 4597 (2007)
Posted by paulmcl to Listeria Hons on Wed Aug 27 2008 at 20:32 UTC | info | related
 
Listeria comet tails: the actin-based motility machinery at work
Anja Lambrechts et al.
Trends in cell biology 18 (5), 220 (04 Apr 2008)
Posted by paulmcl and 1 other to Listeria Hons on Wed Aug 27 2008 at 20:27 UTC | info | related
 
Capping Protein Increases the Rate of Actin-Based Motility by Promoting Filament Nucleation by the Arp2/3 Complex
Cell 133 (5), 841 (2008)
Posted by paulmcl to Listeria Hons on Wed Aug 27 2008 at 20:23 UTC | info | related
 
Listeria monocytogenes multidrug resistance transporters activate a cytosolic surveillance pathway of innate immunity
Proceedings of the National Academy of Sciences 105 (29), 10191 (2008)
An unbiased genetic screen of Listeria monocytogenes mutants that induced an enhanced or diminished host innate immune response showed that the major facilitator superfamily of bacterial multidrug resistance transporters (MDRs) controlled the magnitude of a host cytosolic surveillance pathway, leading to the production of several cytokines. This study may provide insight into the role of the cytosolic surveillance pathway in linking innate and adaptive immunity, thereby leading to the development of adjuvants and vaccines and, perhaps, to the discovery of new therapeutics.
 
Intracellular bacteriolysis triggers a massive apoptotic cell death in Shigella-infected epithelial cells
www.sciencedirect.com
Infected epithelial cells, which act as a first barrier against pathogens, seldom undergo apoptosis. Rather, infected epithelial cells undergo a slow cell death that displays hallmarks of necrosis. Here, we demonstrate that rapid intracellular lysis of Shigella flexneri, provoked by either the use of a diaminopimelic acid auxotroph mutant or treatment of infected cells with antibiotics of the β-lactam family, resulted in a massive and rapid induction of apoptotic cell death. This intracellular bacteriolysis-mediated apoptotic death (IBAD) was characterized by the specific involvement of the mitochondrial-dependent cytochrome c/Apaf-1 axis that resulted in the activation of caspases-3, -6 and -9. Importantly, Bcl-2 family members and the NF-κB pathway seemed to be critical modulators of IBAD. Finally, we identified that IBAD was also triggered by Salmonella enterica serovar Typhimurium but not by the Gram-positive bacteria, Listeria monocytogenes. Together, our results demonstrate that, contrary to previous findings, epithelial cells are intrinsically able to mount an efficient apoptotic cell death response following infection. Indeed, apoptosis in normal circumstances is masked by powerful anti-apoptotic mechanisms, which are overcome in IBAD. Our results also uncover an unexpected consequence of the treatment of infected cells with certain classes of antibiotics.

<< Prev 0      Showing entries 1 to 10 of 95 total      Next 10 >>