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Nature, published online 29 Apr 2009
This paper associates DNA damage response, lifespan and mitochondria.
We describe a new chronological lifespan (CLS) assay for the yeast Schizosaccharomyces pombe Yeast CLS assays monitor the loss of cell viability in a culture over time, and this new assay shows a continuous decline in viability without detectable regrowth until all cells in the culture are dead.
Nature 424 (6946), 277-83 (17 Jul 2003)
Nat Rev Mol Cell Biol 8 (6), 440-50 (Jun 2007)
www.blackwell-synergy.com.proxy.ubn.kun.nl
Experimental gerontology 17 (2), 163-72 (1982)
The FASEB Journal 17 (13), 1960-2 (01 Oct 2003)
DiI: The integrity of sensory amphid neurones is essential for entry into and exit from the dauer pathway and can be assessed by uptake of lipophilic dyes such as DiI. RNAi-treated worms were incubated in 10 ng/mL DiI for 3 h
hsf(RNAi) affecting development, fertility, and life span under standard conditions of growth
C. elegans responds to subtle variations in temperature with alterations in gene expression that affect developmental decisions
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