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Autoantibodies against beta-amyloid are common in Alzheimer's disease and help control plaque burden.
Alexander Kellner et al.
Annals of neurology 65 (1), 24-31 (Jan 2009)
Posted by neurogen to ad Igg Microarray on Thu Mar 12 2009 at 04:01 UTC | info | related
 
Uptake and intra-inclusion accumulation of exogenous immunoglobulin by Chlamydia-infected cells
David V Pollack, Nancy L Croteau, and Elizabeth S Stuart
BMC Microbiology 8 (1), 213 (05 Dec 2008)
Background. Obligate intracellular pathogens belonging to the Chlamydiaceae family possess a number of mechanisms by which to manipulate the host cell and surrounding environment. Such capabilities include the inhibition of apoptosis, down-regulation of major histocompatability complex (MHC) and CD1/d gene expression, and the acquisition of host-synthesized nutrients. It is also documented that a limited number of host-derived macromolecules such as beta-catenin and sphingomyelin accumulate within the inclusion. Results. This report provides evidence that immunoglobulin, inherently present in the extracellular environment in vivo and in vitro, enters infected cells and accumulates within the chlamydial inclusion. Using epi-fluorescent and confocal microscopy, this selective uptake of Ig is shown to occur among human leukocytes in vivo as well as cells cultured in vitro. These findings were confirmed by detection of IgG in the lysate of infected cells by western blot hybridization. Sequestered antibodies appear to be present during the entire course of the chlamydial developmental cycle and are distributed throughout this compartment. IgG pre-labeled with fluorescein, when added to the supernatant of infected cell cultures, was also imported and readily visualized. Accumulation of these molecules within the inclusion and the failure of bovine serum albumin or F(ab')2 fragments to accumulate in a similar manner suggests the process of entry is specific for intact IgG molecules and not a result of pinocytosis, diffusion, or any other mass endocytic event. Conclusions. Sequestration of a host cell-derived protein within the chlamydial inclusion, although unexpected, is not an unprecedented occurrence. However, selective accumulation of an exogenous host protein, such as extracellular IgG, has not been previously reported in connection with chlamydial infections. The selectivity of this process may indicate that this uptake plays an important role in pathogen physiology or virulence during infection and the phenomenon itself may give rise to novel diagnostic and therapeutic approaches.
 
Secretory Component Is Cleaved by Neutrophil Serine Proteinases but its Epithelial Production Is Increased by Neutrophils through NF-{kappa}B- and p38 Mitogen-Activated Protein Kinase-Dependent Mechanisms
Charles Pilette et al.
American Journal of Respiratory Cell and Molecular Biology 28 (4), (01 Apr 2003)
SC translocation in vitro the effects of activated polymorphonuclear neutrophil (PMN) serine proteinases experimental evidence for the Nephritis IgA type association (overlap) 19q13.3 distribution the secretory component (SC or poly-Ig receptor) by translocating polymeric IgA and IgM on the mechanisms of dysregulated expression of pIgR.
Posted by emissrto to chronome HLA-DQA Igg IgA theta on Sun Sep 28 2008 at 05:44 UTC | info | related
 
Localization of ß2-microglobulin in the term villous syncytiotrophoblast
Karl Leitner et al.
Histochemistry and Cell Biology 117 (2), 187-93
6p21.3 encodes a novel nonclassical MHC class-1-like molecule such as _ FcRn_(FC fragment of the IgG receptor alpha) or the protein (HFE) in the context of a 5' UTR Kozak sequence, proposed to co-operate with divalent-metal-transporter-1 [SLC11A2] and FPN1 [SLC40A1] and two oxidoreductases Dcytb, hephaestin, respectively are positively related to each other independently of the underlying disease,
Posted by emissrto to HLA-DQA SLC11A2 beta2 Igg MHC on Sun Sep 28 2008 at 04:53 UTC | info | related
 
Activation of natural regulatory T cells by IgG Fc-derived Peptide "Tregitopes"
Blood, (2008)
Posted by lum141ty to Igg Treg Fc on Mon Jul 28 2008 at 15:21 UTC | info | related
 
Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1
D Pei, J Wang, and C T Walsh
Proceedings of the National Academy of Sciences of the United States of America 93 (3), 1141-5 (06 Feb 1996)
 
Immunity -- Entry Route of Salmonella typhimurium Directs the Type of Induced Immune Response
www.immunity.com
Secretory immunoglobulin A (SIgA) represents a first line of defense against mucosal pathogens by limiting their entrance. By using different strains of Salmonella typhimurium that target the two mechanisms of bacterial entry (microfold cell [M cell]- or dendritic cell-mediated), we demonstrated here that the distribution of bacteria after oral infection directed the type of induced immune response. M cell-penetrating invasive, but not noninvasive, S. typhimurium was found in large numbers in Peyer's patches (PPs), leading to the activation of immune cells and the release of fecal IgA. In contrast, both strains of bacteria were equally capable of reaching the mesenteric lymph node and the spleen and inducing IgG responses. These data suggest that PPs are absolutely required for the initiation of an IgA response to Salmonella, whereas they are dispensable for a systemic response. This compartmentalization could allow the fast generation of both mucosal and systemic acquired immunity to pathogens.
 
Elisa kit evaluation for IGG and IGM antibodies to A-60 tubercular protein antigen.
Y Kalantri et al.
Indian journal of medical sciences 59 (8), 337-46 (Aug 2005)
 
Evaluation of human IgG subclass antibodies in the serodiagnosis of Paragonimiasis heterotremus.
Chaisiri Wongkham et al.
Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand 23 (4), 205-11 (Dec 2005)
Posted by DIEGOFCERQUERA to tipos Igg de on Mon Nov 05 2007 at 23:11 UTC | info | related
 
Dehydroepiandrosterone sulphate enhances IgG and Interferon-gamma production during immunization to tuberculosis in young but not aged mice.
Flávia Ribeiro et al.
Biogerontology 8 (2), 209-20 (Apr 2007)

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