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Cell Death Differ, (13 Mar 2009)
"our study provides a framework for future analysis of molecular signaling during ESC neuralization."
Nat Meth 2 (3), 185-90 (Mar 2005)
Demonstrate that hESCs cultured in unconditioned medium (UM) are subjected to high levels of BMP signaling activity, which is reduced in CM. The BMP antagonist noggin synergizes with basic fibroblast growth factor (bFGF) to repress BMP signaling and sustain undifferentiated proliferation of hESCs in the absence of fibroblasts or CM.
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