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Bioinformatics 24 (13), i59 (01 Jul 2008)
dx.plos.org
The development, survival, and reproduction of an organism depend on the genetic information that is carried in its genome, yet the transmission of genetic information is not perfectly accurate: new mutations occur at each generation.
Genome Biology and Evolution 2009, 114 (2009)
Published estimates of the proportion of positively selected genes (PSGs) in human vary over three orders of magnitude. In mammals, estimates of the proportion of PSGs cover an even wider range of values. We used 2,980 orthologous protein-coding genes from human, chimpanzee, macaque, dog, cow, rat, and mouse as well as an established phylogenetic topology to infer the fraction of PSGs in all seven terminal branches.
Genetics 182 (1), 217-31 (01 May 2009)
We propose a novel approximate-likelihood method to fit demographic models to human genomewide single-nucleotide polymorphism (SNP) data. We divide the genome into windows of constant genetic map width and then tabulate the number of distinct haplotypes and the frequency of the most common haplotype for each window.
Genetics 182 (2), 575-93 (01 Jun 2009)
Traditional methods for analyzing population structure, such as the Structure program, ignore the influence of the effect of allele mutations between the ancestral and current alleles of genetic markers, which can dramatically influence the accuracy of the structural estimation of current populations.
BMC Genetics 10 (1), 27 (2009)
Although high-throughput genotyping arrays have made whole-genome association studies (WGAS) feasible, only a small proportion of SNPs in the human genome are actually surveyed in such studies. In addition, various SNP arrays assay different sets of SNPs, which leads to challenges in comparing results and merging data for meta-analyses. Genome-wide imputation of untyped markers allows us to address these issues in a direct fashion.
PASS a Program to Align Short Sequences
Bioinformatics (Oxford, England) 25 (7), (13 Feb 2009)
www.ploscompbiol.org
Trends in genetics : TIG 24 (3), 133-41 (Mar 2008)
Nature 265 (5596), 687-95 (24 Feb 1977)
Nucleotide sequence of bacteriophage phi X174 DNA
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