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Pharmacogenomics 9 (12), 1809-23 (Dec 2008)
Proceedings of the National Academy of Sciences, (2009)
Our results highlight the potential significance of epigenetic modifications, such as DNA methylation, in developmental processes in social insects. In particular, the pervasiveness of DNA methylation in the genome of A. mellifera provides fertile ground for future studies of phenotypic plasticity and genomic imprinting.
Genes and Development 20 (23), 3215-31 (01 Dec 2006)
Role of protein methylation in regulation of transcription
Endocrine reviews 26 (2), 147-70 (01 Apr 2005)
Oncogene 20 (24), 3014-20 (28 May 2001)
dx.plos.org
DNA methylation is defined as an epigenetic modification because it can be inherited across cell division. Since variations in DNA methylation can affect gene expression and be inherited across generations, they can provide a source of heritable phenotypic variation that is not caused by changes in the DNA sequence. However, the extent to which this type of phenotypic variation occurs in natural or experimental populations is unknown
Nat Neurosci, published online 07 Jun 2009
Nat Rev Micro 7 (7), 504-13 (Jul 2009)
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