http://projectnatalxbox101.blogspot.com/

cells stebly expressing E1A after infection have higher effect of the E3 downregulation of MHC class-I, thus these cells function as reservoirs for the virus = presistent infection.

MHC downregulation in Ad5 infected 293

In this report, we investigate further the mechanisms governing assembly of BC-box proteins with their specific Cul-Rbx modules. Through purification and characterization of a larger collection of BC-box proteins that serve as substrate recognition subunits of CBC ubiquitin ligases and through structure-function studies, we define Cul2- and Cul5-boxes in greater detail. Although it previously appeared that there was little sequence similarity between Cul5- and Cul2- box motifs, analyses of newly identified BC-box proteins that assemble into Cul2 ubiquitin ligases reveal that residues conserved in the Cul2-box represent a subset of those conserved in the Cul5-box.

After several years of rumors and guesswork, Olympus presented a new 10-Mp digital camera Olympus E-3, which will replace previous model E-1. The novelty will cost about $2200. Flagship model Olympus E-3 (of the standard 4/3) is developed for professional users, for whom maximum speed, functionality and reliability is important.