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DNA repair pathways as targets for cancer therapy
Thomas Helleday et al.
Nature reviews. Cancer 8 (3), 193-204 (Mar 2008)
 
DNA Sudoku--harnessing high-throughput sequencing for multiplexed specimen analysis
Genome Research, (2009)
Posted by LisaGreen to multiplexing DNA on Tue Jun 30 2009 at 20:31 UTC | info | related
 
Genome-wide screen of promoter methylation identifies novel markers in melanoma
Yasuo Koga et al.
Genome Research, (02 Jun 2009)
Posted by lispace to methylation DNA cancer on Tue Jun 30 2009 at 13:28 UTC | info | related
 
Synthetic peptide-based DNA complexes for nonviral gene delivery
Advanced Drug Delivery Reviews 30 (1-3), 115 (1998)
 
The origins and early evolution of DNA mismatch repair genes multiple horizontal gene transfers and co-evolution
The origins and early evolution of DNA mismatch repair genesmultiple horizontal gene transfers and coevolution
Zhenguo Lin, Masatoshi Nei, and Hong Ma
Nucleic acids research 35 (22), 7591-7603 (26 Oct 2007)
To understand the evolutionary process of the DNA mismatch repair system, we conducted systematic phylogenetic analysis of its key components, the bacterial MutS and MutL genes and their eukaryotic homologs. Based on genome-wide homolog searches, we identified three new MutS subfamilies (MutS3-5) in addition to the previously studied MutS1 and MutS2 subfamilies. Detailed evolutionary analysis strongly suggests that frequent ancient horizontal gene transfer (HGT) occurred with both MutS and MutL genes from bacteria to eukaryotes and/or archaea. Our results further imply that the origins of mismatch repair system in eukaryotes and archaea are largely attributed to ancient HGT from bacteria instead of vertical evolution. Specifically, the eukaryotic MutS and MutL homologs likely originated from endosymbiotic ancestors of mitochondria or chloroplasts, indicating that not only archaea, but also bacteria are important sources of eukaryotic DNA metabolic genes. The archaeal MutS1 and MutL homologs were also acquired from bacteria simultaneously through HGT. Moreover, the distribution and evolution profiles of the MutS1 and MutL genes suggest that they have undergone long-term coevolution. Our work presents an overall portrait of the evolution of these important genes in DNA metabolism and also provides further understanding about the early evolution of cellular organisms.
 
DNA Used To Identify Jeffery Dahmer's Victims Parts
Unsolved Mysteries - The Worlds Unexplained Mysteries, (24 Jun 2009)
Jeffery Dahmer was known nationally as the sickest of all serial killers in the world. His victim's bodies were mutilated and de-skinned with chemicals
 
DNA directed protein immobilization on mixed ssDNA/OEG SAMs
pubs.acs.org
 
Controlling DNA Orientation on Mixed ssDNA/OEG SAMs
pubs.acs.org
 
DNA sequence Reverse and Complement
www.cellbiol.com
Posted by bs08htp to reverse DNA sequence on Mon Jun 22 2009 at 21:11 UTC | info | related
 
A virus DNA gate: Zipping and unzipping the packed viral genome
Venigalla Rao
Proceedings of the National Academy of Sciences 106 (21), (26 May 2009)
Posted by ChemGenomics to DNA on Fri Jun 19 2009 at 16:25 UTC | info | related

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