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Journal of the American Geriatrics Society 48 (12), 1679-89 (2000)
www.ft.com
Surgeons are widely regarded as the monarchs of medicine. Their intellectual brilliance and manual dexterity may indeed be outstanding but there is one vital aspect of healthcare in which they lag behind the medical profession as a whole: research.
The New England Journal of Medicine 360 (8), 824-30 (19 Feb 2009)
Issues with registration of clinical trials
Circulation 119 (13), (07 Apr 2009)
Pilot trials are exploratory studies limited in size and scope that give insight into the actions, efficacy, and safety of a drug or device but cannot provide definitive support for specific mechanistic or therapeutic claims. I feel it is important to appreciate their appropriate use and key limitations for clinical and translational cardiovascular research.
BMJ 338 (apr03_1), b1147 (03 Apr 2009)
Identified methodological problems were an unclear understanding of underlying assumptions, inappropriate search and selection of relevant trials, use of inappropriate or flawed methods, lack of objective and validated methods to assess or improve trial similarity, and inadequate comparison or inappropriate combination of direct and indirect evidence. Adequate understanding of basic assumptions underlying indirect and mixed treatment comparison is crucial to resolve these methodological problems.
JNCI Journal of the National Cancer Institute 101 (2), 72 (2009)
Nat Clin Prac Oncol 3 (1), 24-40 (Jan 2006)
The Lancet Oncology 8 (12), 1079 (2007)
The lancet oncology 8 (12), 1071-8 (Dec 2007)
Nat Clin Pract Gastroenterol Hepatol, published online 20 Jan 2009
This Review presents a 10-step guide to critical appraisal that aims to assist clinicians to identify the most relevant high-quality studies available to guide their clinical practice.
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