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Science 321 (5886), 250-3 (11 Jul 2008)
Science 321 (5886), 246-50 (11 Jul 2008)
Proceedings of the National Academy of Sciences 102 (19), 6679-85 (10 May 2005)
www.pubmedcentral.nih.gov
Chemists are constantly striving for techniques that add
dimensions of orthogonality with increased throughput and
sample complexity. Ion mobility spectrometry (IM) is a gasphase
separation method that adds new dimensions to mass
spectrometry (MS). IM separates gas-phase ions based on
their collision cross-section and can be coupled with timeof-
flight (TOF) mass spectrometry to yield a powerful tool
used in the identification and characterization of proteins and
peptides.A fundamental introduction to IM is presented with
a focus on resolution, sensitivity, and orthogonality coupled
with TOF-MS.
Physical Review B (Condensed Matter and Materials Physics) 77 (16), 165403 (2008)
Physical Review B (Condensed Matter and Materials Physics) 77 (16), 165403 (2008)
Ion Mobility Measurements and their Applications to Clusters and Biomolecules
Journal of Mass Spectrometry 32 (6), 577 (1997)
Ion mobility measurements can be used to obtain structural information for large polyatomic ions in the gas phase. The methods are flexible and can be applied to a wide range of chemical systems. This article reviews the development of these methods and discusses recent applications to complex ions such as atomic clusters and large biomolecules
Biophysical Journal 94 (10), L75-77 (15 May 2008)
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