The objective of this study was to test the hypothesis that the inflammatory response to a high-fat, low-carbohydrate weight loss diet (HF) we previously observed was due to oxidative stress. Nineteen overweight subjects (BMI > 27 kg/m2) were randomly assigned to either an antioxidant supplement (AS) (1 g vitamin C/800 IU vitamin E) or a placebo (P) group and provided with a HF for 7 days. Fasted pre- and post serum samples were measured for markers of inflammation (C-reactive protein (CRP), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1)), oxygen radical absorbance capacity (ORAC), and glucose, whereas urine was measured for oxidative stress (8-epi-prostaglandin-F2(8-epi)). HF resulted in significant reductions in weight (-3.2%), glucose (-18.7%), and MCP-1 (-15%) (all P < 0.01), with no difference between groups. There was a trend for a differential effect between groups for CRP as it decreased 32% in the AS group but increased 50% for P (P = 0.076). Inverse correlations were noted between initial values and changes in several inflammatory and oxidative stress markers, including CRP (r = -0.501), 8-epi (r = -0.863), and ORAC (r = -0.546) (all P < 0.05). It was concluded that weight loss on a short-term HF caused reduction of some but not all markers of inflammation. A role for oxidative stress in causing inflammation was not confirmed; however, longer term diet-controlled studies are necessary to further explore the trend for a differential response in CRP with antioxidant supplementation.

Fruits are a necessary part of the human diet. However, many kids refuse to eat them. So what do you do to get your child to have a higher fruit intake? Juice may be a better alternative.

test to see the difference between connotea tagging and E.D. tagging

We have a complex relationship with bacteria in our world. Bacteria is present in our intestinal tract, skin, urinary tract and women&#8217;s vaginas. Too much bacteria can make us ill and too little can also make us more vulnerable to illness and e...

Antioxidants at Antioxidants for Health