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Recent "Preclinical" articles

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Enhanced neuroprotective effect by combination of bromocriptine and Hypericum perforatum extract against MPTP-induced neurotoxicity in mice
M Mohanasundari et al.
Journal of the neurological sciences 249 (2), 140-4 (15 Nov 2006)
info:pmid/16876826 | info:doi/10.1016/j.jns.2006.06.018
Posted by prasadtd to Superoxide Dismutase Plant Extracts Phytotherapy Parkinsonian Disorders Neuroprotective Agents Muscle Weakness mice Male MPTP Poisoning drug effects locomotion lipid peroxidation Hypericum Hand Strength Glutathione Peroxidase glutathione combination drug therapy Drug Synergism Preclinical Drug Evaluation Dopamine Agonists Dopamine chemistry Corpus Striatum catalase bromocriptine prevention & control etiology ataxia therapeutic use administration & dosage Antiparkinson Agents animals analysis 4-Dihydroxyphenylacetic Acid 3 ref parkinson on Fri Jul 18 2008 at 12:40 UTC | info | related
 
An efficient rapid system for profiling the cellular activities of molecular libraries
Jonathan S Melnick et al.
Proceedings of the National Academy of Sciences of the United States of America. 103 (9), 3153-8 (28 Feb 2006)
info:pmid/16492761 | info:doi/10.1073/pnas.0511292103
Posted by gjwilliams2 to Time Factors structure-activity relationship robotics Reproducibility of Results Pharmacology isolation & purification chemistry Protein Kinase Inhibitors metabolism genetics antagonists & inhibitors Phosphotransferases mice methods Preclinical Drug Evaluation Factual databases Cell Line automation animals on Thu Jul 03 2008 at 00:15 UTC | info | related
 
A genome-wide overexpression screen in yeast for small-molecule target identification
Hendrik Luesch et al.
Chemistry & biology 12 (1), 55-63 (Jan 2005)
info:pmid/15664515 | info:doi/10.1016/j.chembiol.2004.10.015
Posted by gjwilliams2 to Time Factors sorbitol Saccharomyces cerevisiae Proteins growth & development Saccharomyces cerevisiae Non-U.S. Gov't Research Support Pyrimidines Pharmacology chemical synthesis Pyridines metabolism Protein Kinase C Molecular Weight molecular structure Microbial Sensitivity Tests physiology MAP Kinase Signaling System Genomic Library drug effects Gene Expression Regulation genetics fungal Drug resistance methods Preclinical Drug Evaluation on Thu Jul 03 2008 at 00:15 UTC | info | related
 
Identification of selective inhibitors for the glycosyltransferase MurG via high-throughput screening
Yanan Hu et al.
Chemistry & biology 11 (5), 703-11 (May 2004)
info:pmid/15157881 | info:doi/10.1016/j.chembiol.2004.02.024
Posted by gjwilliams2 to N-Acetylglucosaminyltransferases Ligands kinetics antagonists & inhibitors Glycosyltransferases Fluorescence Polarization Enzymology Escherichia coli Pharmacology chemical synthesis Enzyme Inhibitors methods Preclinical Drug Evaluation drug design metabolism chemistry inhibitors antagonists & Bacterial Outer Membrane Proteins animals on Thu Jul 03 2008 at 00:15 UTC | info | related
 
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors
N S Gray et al.
Science. 281 (5376), 533-8 (24 Jul 1998)
info:pmid/9677190
Posted by gjwilliams2 to Cultured Tumor Cells genetic transcription structure-activity relationship Enzymology Saccharomyces cerevisiae Non-P.H.S. U.S. Gov't Non-U.S. Gov't Research Support genetics Messenger RNA chemical synthesis Purines Protein-Serine-Threonine Kinases Piperidines Phosphates Oligonucleotide Probes hydrogen bonding humans Genes fungal Gene Expression Regulation flavonoids Preclinical Drug Evaluation Cyclin-Dependent Kinases Cyclin-Dependent Kinase 2 Cyclin A X-ray crystallography drug effects cell division antagonists & inhibitors S cerevisiae CDC28 Protein Kinase CDC2-CDC28 Kinases binding sites Pharmacology metabolism chemistry analogs & derivatives Adenine on Wed Jul 02 2008 at 23:28 UTC | info | related
 
Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents
Luis Briseño-Roa et al.
Journal of medicinal chemistry 49 (1), 246-55 (12 Jan 2006)
info:pmid/16392809 | info:doi/10.1021/jm050518j
Posted by gjwilliams2 to structure-activity relationship Non-U.S. Gov't Research Support Phosphoric Triester Hydrolases pesticides Organothiophosphorus Compounds Organophosphorus Compounds molecular structure Male kinetics Hydrolysis Guinea Pigs Fluorescent Dyes methods Preclinical Drug Evaluation Coumarins chemical synthesis Cholinesterase Inhibitors toxicity CHEMICAL WARFARE AGENTS chemistry Aryldialkylphosphatase animals drug effects acetylcholinesterase on Wed Jul 02 2008 at 23:28 UTC | info | related
 
Do preclinical findings of methamphetamine-induced motor abnormalities translate to an observable clinical phenotype?
Michael Caligiuri and Casey Buitenhuys
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 30 (12), 2125-34 (Dec 2005)
info:pmid/16123755 | info:doi/10.1038/sj.npp.1300859
Posted by jimdeano to animal Preclinical Methamphetamine on Mon Apr 16 2007 at 13:48 UTC | info | related
 
Panel of Bacillus subtilis reporter strains indicative of various modes of action
Panel of Bacillus subtilis reporter strains indicative of various modes of action
Bernd Hutter et al.
Antimicrobial agents and chemotherapy 48 (7), 2588-94 (Jul 2004)
info:pmid/15215113 | info:doi/10.1128/AAC.48.7.2588-2594.2004
DA - 20040624 IS - 0066-4804 LA - eng PT - Journal Article RN - 0 (Anti-Infective Agents) RN - 0 (DNA Primers) RN - 0 (Fatty Acids) RN - 0 (Genetic Markers) RN - 0 (Plasmids) SB - IM
Posted by ndhoang to Up-Regulation Rifampin Protein Biosynthesis Plasmids Pharmacology kinetics genetics genetic markers Reporter Genes bacterial Gene Expression Regulation fatty acids Preclinical Drug Evaluation drug effects DNA Primers DNA cell wall BIOSYNTHESIS Bacillus subtilis Bacillus Anti-Infective Agents analysis on Mon Jan 08 2007 at 18:52 UTC | info | related
 
Antibiotic-inducible promoter regulated by the cell envelope stress-sensing two-component system LiaRS of Bacillus subtilis
Antibioticinducible promoter regulated by the cell envelope stresssensing twocomponent system LiaRS of Bacillus subtilis
Thorsten Mascher et al.
Antimicrobial agents and chemotherapy 48 (8), 2888-96 (Aug 2004)
info:pmid/15273097 | info:doi/10.1128/AAC.48.8.2888-2896.2004
DA - 20040726 IS - 0066-4804 LA - eng PT - Journal Article RN - 0 (Anti-Bacterial Agents) RN - 0 (Culture Media) RN - 0 (DNA Primers) RN - 0 (DNA, Bacterial) RN - 0 (LiaRS protein, Bacillus subtilis) RN - 0 (Lipids) RN - 0 (Membrane Lipids) RN - 0 (Plasmids) SB - IM
Posted by ndhoang to Solvents Reverse Transcriptase Polymerase Chain Reaction P.H.S. U.S.Gov't Research Support Promoter Regions (Genetics) Plasmids Pharmacology operon microbiology metabolism Membrane Lipids Lipids Lac Operon genetics gene expression Preclinical Drug Evaluation drug effects bacterial DNA Primers DNA Culture Media classification Chromosome Mapping Cell Membrane Northern blotting bacteria Bacitracin Bacillus subtilis Bacillus Anti-Bacterial Agents on Mon Jan 08 2007 at 18:31 UTC | info | related
 
Inhibition of the bacterial surface protein anchoring transpeptidase sortase by medicinal plants
Soo-Whan Kim, Il-Moo Chang, and Ki-Bong Oh
Bioscience, biotechnology, and biochemistry 66 (12), 2751-4 (Dec 2002)
info:pmid/12596883
DA - 20030224 IS - 0916-8451 LA - eng PT - Journal Article RN - 0 (Plant Extracts) RN - EC 2.3.2 (Aminoacyltransferases) RN - EC 2.3.2.- (sortase) SB - IM
Posted by ndhoang to staphylococcus aureus proteins medicinal plants Plant Extracts Pharmacology metabolism Korea isolation & purification Inhibitory Concentration 50 Gram-Positive Bacteria Enzymology Preclinical Drug Evaluation chemistry antagonists & inhibitors Aminoacyltransferases on Mon Jan 08 2007 at 12:43 UTC | info | related

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