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Hsp90 inhibitors identified from a library of novobiocin analogues
Xiao Ming Yu et al.
Journal of the American Chemical Society 127 (37), 12778-9 (21 Sep 2005)
info:pmid/16159253 | info:doi/10.1021/ja0535864
Posted by gjwilliams2 to HSP90 Heat-Shock Proteins Novobiocin N.I.H. Extramural antagonists & inhibitors analogs & derivatives drug effects Cell Line receptors U.S. Gov't tumor Non-U.S. Gov't humans androgen P.H.S. Research Support Pharmacology protein folding structure-activity relationship molecular structure chemistry on Thu Jul 03 2008 at 01:10 UTC | info | related
 
Phagemid encoded small molecules for high throughput screening of chemical libraries
Jun Yin et al.
Journal of the American Chemical Society 126 (42), 13570-1 (27 Oct 2004)
info:pmid/15493886 | info:doi/10.1021/ja045127t
Posted by gjwilliams2 to Transferases (Other Substituted Phosphate Groups) Bacteriophage M13 Peptide Synthases Coenzyme A Combinatorial Chemistry Techniques Bacterial Proteins Oligonucleotide Array Sequence Analysis Peptide Library U.S. Gov't P.H.S. Research Support methods Molecular metabolism genetics DNA cloning chemistry on Thu Jul 03 2008 at 01:10 UTC | info | related
 
Single-cell FRET imaging of transferrin receptor trafficking dynamics by Sfp-catalyzed, site-specific protein labeling
Jun Yin et al.
Chemistry & biology 12 (9), 999-1006 (Sep 2005)
info:pmid/16183024 | info:doi/10.1016/j.chembiol.2005.07.006
Posted by gjwilliams2 to Transferases (Other Substituted Phosphate Groups) transferrin Fluorescence Resonance Energy Transfer Catalysis N.I.H. Extramural Protein Transport Western Bacterial Proteins Cell Line receptors U.S. Gov't P.H.S. Research Support blotting Molecular Endocytosis metabolism cloning on Thu Jul 03 2008 at 01:10 UTC | info | related
 
Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis
Ellen Yeh, Sylvie Garneau, and Christopher T Walsh
Proceedings of the National Academy of Sciences of the United States of America 102 (11), 3960-5 (15 Mar 2005)
info:pmid/15743914 | info:doi/10.1073/pnas.0500755102
Posted by gjwilliams2 to Carbazoles Flavin-Adenine Dinucleotide Indoles Oxidoreductases Tryptophan analogs & derivatives High Pressure Liquid U.S. Gov't BIOSYNTHESIS P.H.S. Research Support kinetics metabolism Chromatography chemistry on Thu Jul 03 2008 at 01:10 UTC | info | related
 
Structure-based enhancement of the first anomeric glucokinase
Jie Yang, Lesley Liu, and Jon S Thorson
Chembiochem : a European journal of chemical biology 5 (7), 992-6 (05 Jul 2004)
info:pmid/15239058 | info:doi/10.1002/cbic.200400041
Posted by gjwilliams2 to Glucokinase Escherichia Site-Directed Carbohydrate Sequence Recombinant Proteins analogs & derivatives isolation & purification Enzymology Molecular Sequence Data U.S. Gov't mutagenesis glucose P.H.S. Research Support Molecular Models metabolism chemical synthesis genetics mutation chemistry on Thu Jul 03 2008 at 01:10 UTC | info | related
 
Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli
N Wymer et al.
Structure (London, England : 1993) 9 (1), 1-9 (10 Jan 2001)
info:pmid/11342129
Posted by gjwilliams2 to Aldehyde-Lyases Site-Directed Catalytic Domain Catalysis Lysine Gene Library secondary Substrate Specificity Matrix-Assisted Laser Desorption-Ionization Enzymology crystallography U.S. Gov't mass mutagenesis Non-U.S. Gov't Escherichia coli spectrometry P.H.S. Research Support binding sites chemical Molecular Models kinetics metabolism X-ray protein structure mutation chemistry on Thu Jul 03 2008 at 01:10 UTC | info | related
 
Post-translational modification of polyketide and nonribosomal peptide synthases
C T Walsh et al.
Current opinion in chemical biology 1 (3), 309-15 (Oct 1997)
info:pmid/9667867
Posted by gjwilliams2 to Transferases (Other Substituted Phosphate Groups) Multienzyme Complexes Protein Processing Post-Translational Peptides fatty acids U.S. Gov't BIOSYNTHESIS Non-U.S. Gov't P.H.S. Research Support metabolism on Thu Jul 03 2008 at 01:10 UTC | info | related
 
Chorismate aminations: partial purification of Escherichia coli PABA synthase and mechanistic comparison with anthranilate synthase
C T Walsh et al.
Biochemistry 26 (15), 4734-45 (28 Jul 1987)
info:pmid/3311153
Posted by gjwilliams2 to Chorismic Acid Cyclohexanecarboxylic Acids Anthranilate Synthase Serratia marcescens transaminases Plasmids analogs & derivatives isolation & purification Enzymology Magnetic Resonance Spectroscopy Indicators and Reagents U.S. Gov't Escherichia coli COMPARATIVE STUDY P.H.S. Research Support Pharmacology bacterial kinetics metabolism structure-activity relationship chemical synthesis Genes genetics on Thu Jul 03 2008 at 01:10 UTC | info | related
 
Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase
Claire C Tseng et al.
Biochemistry 41 (45), 13350-9 (12 Nov 2002)
info:pmid/12416979
Posted by gjwilliams2 to Boronic Acids Peptide Synthases Cyclic beta-Alanine Thiolester Hydrolases macrolides cysteamine Site-Directed Anti-Bacterial Agents Bacillus subtilis antagonists & inhibitors Substrate Specificity analogs & derivatives Bacterial Proteins Tertiary Peptide Fragments Enzymology crystallography Peptides Hydrolysis Amino Acid Sequence Enzyme Inhibitors U.S. Gov't mutagenesis Non-U.S. Gov't P.H.S. Research Support X-ray chemical synthesis protein structure genetics chemistry on Thu Jul 03 2008 at 01:10 UTC | info | related
 
Cyclization of backbone-substituted peptides catalyzed by the thioesterase domain from the tyrocidine nonribosomal peptide synthetase
J W Trauger, R M Kohli, and C T Walsh
Biochemistry 40 (24), 7092-8 (19 Jun 2001)
info:pmid/11401554
Posted by gjwilliams2 to Peptide Synthases Cyclic Thiolester Hydrolases lactones cysteamine Catalysis Amino Acid Substitution Substrate Specificity analogs & derivatives Tertiary hydrogen bonding Peptides Protein Conformation U.S. Gov't P.H.S. Research Support metabolism chemical synthesis protein structure on Thu Jul 03 2008 at 01:10 UTC | info | related

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