changes in transcription patterns brought about by overall alterations in the chromatin conformation

Is almost a copy (too bad!) of an older article by Laurence Hurst http://www.ncbi.nlm.nih.gov/pubmed/17660811?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3

Look more into the webserver http://bioinformatics1.smb.wsu.edu/Ceres

Correlating the GC content with nucleosome positioning appears to be the main sequence underlying feature

a method for deep-seq analyzing, plus evidence for susceptible to eviction nucleosomes

do I need to say told you so?

Complex transcriptional behaviours are encoded in the DNA sequences of gene regulatory regions. Advances in our understanding of these behaviours have been recently gained through quantitative models that describe how molecules such as transcription factors and nucleosomes interact with genomic sequences. An emerging view is that every regulatory sequence is associated with a unique binding affinity landscape for each molecule and, consequently, with a unique set of molecule-binding configurations and transcriptional outputs. We present a quantitative framework based on existing methods that unifies these ideas. This framework explains many experimental observations regarding the binding patterns of factors and nucleosomes and the dynamics of transcriptional activation. It can also be used to model more complex phenomena such as transcriptional noise and the evolution of transcriptional regulation.