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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus.
www.ncbi.nlm.nih.gov
Posted by magidm00 and 187 others with 19 comments to Mdm2 Akt PI3K on Mon Jul 21 2008 at 17:25 UTC | info | related
 
Immunoreactivity of p53, Mdm2, p21(WAF1/CIP1) Bcl-2, and Bax in soft tissue sarcomas: correlation with histologic grade.
Muna Sabah et al.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 15 (1), 64-9 (Mar 2007)
info:pmid/17536310
Posted by pbaleixo to grade Sarcoma Mdm2 p53 on Sat May 10 2008 at 18:26 UTC | info | related
 
Significance of retinoblastoma and mdm2 gene expression as prognostic markers for soft-tissue sarcoma.
P Würl et al.
Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie 383 (1), 99-103 (Mar 1998)
info:pmid/9627179
Posted by pbaleixo to prognostico retinoblastoma Mdm2 liposarcoma on Sat May 10 2008 at 18:15 UTC | info | related
 
HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon.
Antoine Italiano et al.
International journal of cancer. Journal international du cancer 122 (10), 2233-41 (15 May 2008)
info:pmid/18214854 | info:doi/10.1002/ijc.23380
Posted by pbaleixo to HMGA2 CDK4 Mdm2 liposarcoma on Sun Apr 27 2008 at 03:12 UTC | info | related
 
p73 expression modulates p63 and Mdm2 protein presence in complex with p53 family-specific DNA target sequence in squamous cell carcinogenesis
J Johnson et al.
Oncogene 27 (19), 2780-7 (19 Nov 2007)
Posted by s9753195 to SCC Mdm2 on Thu Apr 24 2008 at 14:09 UTC | info | related
 
Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells
P Wang et al.
Oncogene 27 (11), 1590-8 (10 Sep 2007)
Posted by Sharonb to cMyc Mdm2 on Fri Mar 07 2008 at 15:18 UTC | info | related
 
A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop
Lei Xiong et al.
The Journal of Cell Biology 178 (6), 995-1007 (10 Sep 2007)
info:doi/10.1083/jcb.200703044
Posted by magidm00 to Feedback loop Apoptosis Mdm2 p53 IGF-1R on Wed Dec 12 2007 at 20:42 UTC | info | related
 
p53 and Mdm2: not all cells are equal
P Coates
The Journal of Pathology 9999 (9999), n-a (2007)
info:doi/10.1002/path.2275
Posted by pbaleixo to Mdm2 on Fri Nov 02 2007 at 14:57 UTC | info | related
 
Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1.
R Vasilcanu et al.
Oncogene, (10 Sep 2007)
info:pmid/17828296 | info:doi/10.1038/sj.onc.1210797
Posted by yyshi1 to Mdm2 IGF1R on Sat Oct 27 2007 at 03:57 UTC | info | related
 
A Single Nucleotide Polymorphism in the MDM2 Gene Disrupts the Oscillation of p53 and MDM2 Levels in Cells
Cancer Research 67 (6), 2757 (2007)
info:doi/10.1158/0008-5472.can-06-2656
P53 and MDM2 protein levels have been shown to oscillate upon genotoxic stress. A mathematical model of P53/MDM2 dynamics predicts that elevated levels of MDM2 would make the oscillation disappear. Independently, Arnie and his group have shown that elevated MDM2 levels are created by SNP309 (T->G), that reinforces a Sp1 binding site. In this paper, the authors show that SNP309 indeed suppresses oscillations. Moreover SNP309 makes MDM2 transcription estrogen-dependent on.
Posted by oelemento to modeling Mdm2 p53 arnie stolovitsky columbia cancer on Tue Sep 18 2007 at 03:21 UTC | info | related

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