Mesoscale simulations have recently been developed in order to better understand the collective behaviour of dislocations and their effects on the mechanical response. Those simulations deal with dislocations discretized into segments which are allowed to move in a three-dimensional (3D) discrete network. This network is a sublattice of the original crystalline lattice network. The minimum distance between two points is defined by the annihilation distance for two edge dislocations, i.e. the minimum distance for which two edge dislocations can coexist without instantaneous collapse. The elastic theory can still be applied in the simulated volume, since the minimum distance is large compared to the dislocation core radius within which nonlinear expressions should be taken into account in the dislocation-dislocation interaction. This property allows us to use the superposition principle to enforce boundary conditions on the simulation box. This paper details the rigorous boundary conditions applied when the simulation box is supposed to be either a bulk crystal, a free standing film or a finite crystal submitted to a complex loading.

In the present paper, an infinite face-centered cubic single crystal containing an isolated cylindrical micron-sized void, which is subjected to proportional and monotonically uniform equal biaxial tension loading, is adopted to study the scale-dependent void growth and its intrinsic mechanism by employing a two-dimensional planar discrete dislocation dynamic framework. First, a typical dislocation distribution near the microvoid is presented and the void growth mechanism is revealed by dislocation shear loop expansion for each of three typical fcc slip systems. The effect of size on void growth is then investigated. The general conclusion that voids at the micron or submicron scale are less susceptible to growth than larger ones is drawn. Another result, which cannot be deduced from the continuum theories, is also achieved: at the micron or submicron scale, larger voids grow smoothly with remote strain, while smaller voids usually grow in a "leapfrog" manner. Specifically, when the void is even smaller, it grows in an approximately linear-elastic manner since only few dislocations are present around the void. Further analyses indicate that these size effects are closely related to the dislocation density on the void surface and the dislocation mobility around the void. Finally, the influences of the dislocation sources/obstacles density and their random distribution in materials on the void growth are studied briefly. Results show that there exists remarkable scatter in the microvoid growth due to random distribution of the dislocation sources or obstacles, especially for voids at the submicron scale. These results are helpful for us in understanding the size-dependent damage mechanism at the micron or submicron scale. ? 2006 Acta Materialia Inc.

Times Cited: 2

Normal tissue cells are generally not viable when suspended in a fluid and are therefore said to be anchorage dependent. Such cells must adhere to a solid, but a solid can be as rigid as glass or softer than a baby?s skin. The behavior of some cells on soft materials is characteristic of important phenotypes; for example, cell growth on soft agar gels is used to identify cancer cells. However, an understanding of how tissue cells-including fibroblasts, myocytes, neurons, and other cell types-sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels (or to other cells) with which elasticity can be tuned to approximate that of tissues. Key roles in molecular pathways are played by adhesion complexes and the actinmyosin cytoskeleton, whose contractile forces are transmitted through transcellular structures. The feedback of local matrix stiffness on cell state likely has important implications for development, differentiation, disease, and regeneration.