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Recent "Cyclic" articles

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Stoichiometry and specificity of in vitro phosphopantetheinylation and aminoacylation of the valine-activating module of surfactin synthetase
P H Weinreb et al.
Biochemistry 37 (6), 1575-84 (10 Feb 1998)
info:pmid/9484228 | info:doi/10.1021/bi9719859
Posted by gjwilliams2 to Valine Transferases (Other Substituted Phosphate Groups) Substrate Specificity P.H.S. U.S. Gov't Research Support Recombinant Proteins Post-Translational Protein Processing Cyclic Peptides Peptide Synthases analogs & derivatives Pantetheine kinetics chemical synthesis BIOSYNTHESIS Genetic Vectors genetics Escherichia coli Enzyme Stability Catalysis chemistry Bacterial Proteins Enzymology Bacillus subtilis Aminoacyltransferases metabolism Adenosine Monophosphate Acylation on Thu Jul 03 2008 at 01:10 UTC | info | related
 
Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase
Claire C Tseng et al.
Biochemistry 41 (45), 13350-9 (12 Nov 2002)
info:pmid/12416979
Posted by gjwilliams2 to beta-Alanine Thiolester Hydrolases Substrate Specificity P.H.S. U.S. Gov't Non-U.S. Gov't Research Support Tertiary protein structure chemical synthesis Cyclic Peptides Peptide Synthases antagonists & inhibitors Peptide Fragments Site-Directed mutagenesis macrolides Hydrolysis Enzyme Inhibitors analogs & derivatives cysteamine X-ray crystallography Boronic Acids Bacterial Proteins genetics Enzymology Bacillus subtilis chemistry Anti-Bacterial Agents Amino Acid Sequence on Thu Jul 03 2008 at 01:10 UTC | info | related
 
Cyclization of backbone-substituted peptides catalyzed by the thioesterase domain from the tyrocidine nonribosomal peptide synthetase
J W Trauger, R M Kohli, and C T Walsh
Biochemistry 40 (24), 7092-8 (19 Jun 2001)
info:pmid/11401554
Posted by gjwilliams2 to Thiolester Hydrolases Substrate Specificity P.H.S. U.S. Gov't Research Support Tertiary protein structure Protein Conformation Cyclic Peptides Peptide Synthases lactones hydrogen bonding metabolism chemical synthesis analogs & derivatives cysteamine Catalysis Amino Acid Substitution on Thu Jul 03 2008 at 01:10 UTC | info | related
 
Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases
Dirk Schwarzer et al.
Proceedings of the National Academy of Sciences of the United States of America 99 (22), 14083-8 (29 Oct 2002)
info:pmid/12384573 | info:doi/10.1073/pnas.212382199
Posted by gjwilliams2 to Tyrocidine Thiolester Hydrolases Ribosomes isolation & purification Recombinant Fusion Proteins Cyclic Peptides Peptide Synthases Malonyl Coenzyme A kinetics Hydrolysis gene expression BIOSYNTHESIS fatty acids purification isolation & Fatty Acid Synthetase Complex Escherichia coli Proteins Enzyme Activation Catalysis Bacterial Proteins chemistry Bacitracin genetics Enzymology Bacillus Apoproteins amino acids metabolism Acyl Carrier Protein on Thu Jul 03 2008 at 00:50 UTC | info | related
 
The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a non-ribosomal lipopeptide
Stefan A Samel et al.
Journal of molecular biology 359 (4), 876-89 (16 Jun 2006)
info:pmid/16697411 | info:doi/10.1016/j.jmb.2006.03.062
Posted by gjwilliams2 to Thiolester Hydrolases Protein Structural Homology Amino Acid Sequence Homology Ribosomal Proteins Tertiary protein structure Protein Conformation Phenylmethylsulfonyl Fluoride Cyclic Peptides antagonists & inhibitors Peptide Synthases Nucleic Acid-Independent Peptide Biosynthesis Molecular Sequence Data Molecular Models BIOSYNTHESIS lipoproteins X-ray crystallography Catalytic Domain binding sites chemistry Bacterial Proteins metabolism Enzymology Bacillus subtilis Amino Acid Sequence on Thu Jul 03 2008 at 00:50 UTC | info | related
 
Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases
L E Quadri et al.
Biochemistry 37 (6), 1585-95 (10 Feb 1998)
info:pmid/9484229 | info:doi/10.1021/bi9719861
Posted by gjwilliams2 to Substrate Specificity P.H.S. U.S. Gov't Research Support isolation & purification Recombinant Proteins Tertiary protein structure Cyclic chemical synthesis Peptides purification isolation & BIOSYNTHESIS Peptide Synthases Site-Directed mutagenesis Molecular Sequence Data lipoproteins Escherichia coli Conserved Sequence metabolism Coenzyme A Carrier Proteins chemistry Bacterial Proteins genetics Enzymology Bacillus subtilis Amino Acid Sequence on Thu Jul 03 2008 at 00:15 UTC | info | related
 
The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography
R J Lewis et al.
The EMBO journal 15 (6), 1412-20 (15 Mar 1996)
info:pmid/8635474
Posted by gjwilliams2 to Cyclic Peptides Peptide Fragments Novobiocin Molecular Models Enzymology Escherichia coli Enzyme Inhibitors antagonists & inhibitors Type II DNA Topoisomerases DNA Gyrase X-ray crystallography chemistry Adenylyl Imidodiphosphate on Thu Jul 03 2008 at 00:15 UTC | info | related
 
Biomimetic synthesis and optimization of cyclic peptide antibiotics
Rahul Kohli, Christopher Walsh, and Michael Burkart
Nature 418 (6898), 658-61 (08 Aug 2002)
info:pmid/12167866 | info:doi/10.1038/nature00907
Posted by gjwilliams2 to synthesis chemical analogs & derivatives Tyrocidine metabolism Thiolester Hydrolases Substrate Specificity P.H.S. U.S. Gov't Research Support Cyclic Peptides Molecular Sequence Data Molecular Mimicry Microbial Sensitivity Tests Hydrolysis humans erythrocytes Cyclization Catalysis Biological Products drug effects bacteria Pharmacology chemical synthesis BIOSYNTHESIS Anti-Bacterial Agents Amino Acid Sequence on Thu Jul 03 2008 at 00:15 UTC | info | related
 
Monocyclic human tachykinin NK-2 receptor antagonists as evolution of a potent bicyclic antagonist: QSAR and site-directed mutagenesis studies
Alessandro Giolitti et al.
Journal of medicinal chemistry 45 (16), 3418-29 (01 Aug 2002)
info:pmid/12139452
Posted by gjwilliams2 to Tachykinins metabolism antagonists & inhibitors Neurokinin-2 receptors Radioligand Assay Quantitative Structure-Activity Relationship Pharmacology chemistry chemical synthesis Cyclic Peptides Site-Directed mutagenesis Molecular Sequence Data Molecular Mimicry Molecular Conformation Molecular Models Ligands In Vitro humans competitive binding binding sites Amino Acid Sequence on Wed Jul 02 2008 at 23:28 UTC | info | related
 
Antitumor antibiotics: bleomycin, enediynes, and mitomycin
Ute Galm et al.
Chemical reviews 105 (2), 739-58 (Feb 2005)
info:pmid/15700963 | info:doi/10.1021/cr030117g
Posted by gjwilliams2 to P.H.S. Non-P.H.S. U.S. Gov't Non-U.S. Gov't Research Support Cyclic Peptides molecular structure mitomycin Neoplasm Drug resistance Bleomycin Pharmacology chemistry BIOSYNTHESIS Antineoplastic antibiotics animals on Wed Jul 02 2008 at 23:28 UTC | info | related

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