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CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis
Michelle Pacholec, Junhua Tao, and Christopher T Walsh
Biochemistry 44 (45), 14969-76 (15 Nov 2005)
info:pmid/16274243 | info:doi/10.1021/bi051599o
Posted by gjwilliams2 to Enzymology Streptomyces Non-P.H.S. U.S. Gov't Extramural N.I.H. Research Support Novobiocin isolation & purification Methyltransferases kinetics genetics Escherichia coli BIOSYNTHESIS Anti-Bacterial Agents metabolism chemistry Aminocoumarins on Thu Jul 03 2008 at 00:15 UTC | info | related
 
Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway
Michelle Pacholec et al.
Biochemistry 44 (12), 4949-56 (29 Mar 2005)
info:pmid/15779922 | info:doi/10.1021/bi047303g
Posted by gjwilliams2 to Substrate Specificity Enzymology Streptomyces antibioticus P.H.S. Non-P.H.S. U.S. Gov't Extramural N.I.H. Research Support analogs & derivatives Novobiocin Glycosides bacterial Gene Expression Regulation Coumarins metabolism Carboxylic Acids Pharmacology Anti-Bacterial Agents Aminocoumarins isolation & purification genetics chemistry BIOSYNTHESIS Amide Synthases on Thu Jul 03 2008 at 00:15 UTC | info | related
 
Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins
M G Marcu, T W Schulte, and L Neckers
Journal of the National Cancer Institute 92 (3), 242-8 (02 Feb 2000)
info:pmid/10655441
Posted by gjwilliams2 to Tumor Suppressor Proteins Tumor Suppressor Protein p53 Cultured Tumor Cells cytology Spleen signal transduction Proto-Oncogene Proteins c-raf Protein Binding Oncogene Protein pp60(v-src) analogs & derivatives Novobiocin mice Intracellular Signaling Peptides and Proteins humans HSP90 Heat-Shock Proteins fibroblasts female Enzyme Inhibitors antagonists & inhibitors Type II DNA Topoisomerases Coumarins metabolism drug effects Carrier Proteins carcinoma drug therapy Breast Neoplasms Western blotting Pharmacology chemistry Antineoplastic antibiotics animals Aminocoumarins on Thu Jul 03 2008 at 00:15 UTC | info | related
 
The interaction of coumarin antibiotics with fragments of DNA gyrase B protein
N A Gormley et al.
Biochemistry 35 (15), 5083-92 (16 Apr 1996)
info:pmid/8664301 | info:doi/10.1021/bi952888n
Posted by gjwilliams2 to Non-U.S. Gov't Research Support protein folding analogs & derivatives Novobiocin kinetics antagonists & inhibitors Type II DNA Topoisomerases DNA Gyrase Cross-Linking Reagents Coumarins binding sites metabolism Anti-Bacterial Agents Aminocoumarins Pharmacology Adenylyl Imidodiphosphate on Wed Jul 02 2008 at 23:28 UTC | info | related
 
Installation of the pyrrolyl-2-carboxyl pharmacophore by CouN1 and CouN7 in the late biosynthetic steps of the aminocoumarin antibiotics clorobiocin and coumermycin A1
Sylvie Garneau-Tsodikova et al.
Biochemistry 45 (28), 8568-78 (18 Jul 2006)
info:pmid/16834331 | info:doi/10.1021/bi060784e
Posted by gjwilliams2 to Enzymology Streptomyces Research Support, N.I.H., Extramural Recombinant Proteins analogs & derivatives Novobiocin kinetics Genes, Fungal Escherichia coli Cloning, Molecular Catalysis Antibiotics, Antineoplastic Aminocoumarins metabolism Adenosine Monophosphate genetics chemistry BIOSYNTHESIS Acyltransferases on Wed Jul 02 2008 at 23:28 UTC | info | related
 
Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis
Sylvie Garneau et al.
Biochemistry 44 (8), 2770-80 (01 Mar 2005)
info:pmid/15723521 | info:doi/10.1021/bi0476329
Posted by gjwilliams2 to Matrix-Assisted Laser Desorption-Ionization mass spectrometry Restriction Mapping P.H.S. U.S. Gov't Research Support Pyrroles polymerase chain reaction purification isolation & BIOSYNTHESIS analogs & derivatives Novobiocin Molecular Sequence Data Molecular Conformation Molecular Models Escherichia coli Proteins genetics Escherichia coli DNA Primers isolation & purification chemistry Coumarins High Pressure Liquid Chromatography Aminocoumarins Amino Acid Sequence on Wed Jul 02 2008 at 23:28 UTC | info | related
 
Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN
Caren L Freel Meyers et al.
Biochemistry 43 (47), 15022-36 (30 Nov 2004)
info:pmid/15554710 | info:doi/10.1021/bi048457z
Posted by gjwilliams2 to Variation (Genetics) Substrate Specificity Streptomyces mass Spectrum Analysis P.H.S. U.S. Gov't Research Support molecular structure Ligases Glycosyltransferases genetics Escherichia coli dimerization metabolism Coumarins Liquid Chromatography isolation & purification chemistry BIOSYNTHESIS Anti-Bacterial Agents Aminocoumarins on Wed Jul 02 2008 at 23:28 UTC | info | related
 
Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry
Pieter C Dorrestein et al.
Biochemistry 45 (6), 1537-46 (14 Feb 2006)
info:pmid/16460000 | info:doi/10.1021/bi052333k
Posted by gjwilliams2 to Thiazoles Sulfhydryl Compounds Substrate Specificity methods Spectrum Analysis, Mass Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural Pyrrolidinones Phenols Peptide Synthases analogs & derivatives Novobiocin Multigene Family enterobactin Catalytic Domain bromine genetics Enzymology Bacillus subtilis Aminoglycosides chemistry Aminocoumarins metabolism Adenosine Triphosphate on Wed Jul 02 2008 at 23:28 UTC | info | related
 
Nucleotide sequence of the adi gene, which encodes the biodegradative acid-induced arginine decarboxylase of Escherichia coli
K P Stim and G N Bennett
Journal of bacteriology. 175 (5), 1221-34 (Mar 1993)
info:pmid/8383109
DA - 19930405 IS - 0021-9193 (Print) LA - eng PT - Journal Article RN - 0 (Aminocoumarins) RN - 0 (Coumarins) RN - 0 (DNA Transposable Elements) RN - 0 (DNA, Bacterial) RN - 303-81-1 (Novobiocin) RN - 4434-05-3 (coumermycins) RN - EC 4.1.1. (Carboxy-Lyases) RN - EC 4.1.1.19 (arginine decarboxylase) RN - EC 5.99.1.3 (DNA Topoisomerases, Type II) SB - IM
Posted by dah74591 to Amino Acid Sequence Homology P.H.S. U.S.Gov't Non-U.S.Gov't Research Support Promoter Regions (Genetics) Pharmacology operon Novobiocin Site-Directed mutagenesis Molecular Weight Molecular Sequence Data metabolism Hydrogen-Ion Concentration genetics Genes Gene Expression Regulation Escherichia coli Enzymology drug effects DNA Transposable Elements Type II DNA Topoisomerases DNA Coumarins COMPARATIVE STUDY bacterial Chromosomes Carboxy-Lyases biodegradation biochemistry Base Sequence analysis Anaerobiosis Aminocoumarins amino acids Amino Acid Sequence acids on Fri Oct 27 2006 at 17:02 UTC | info | related

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